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Antibody clustering helps refine lupus prognosis.
- Source :
-
Seminars in arthritis and rheumatism [Semin Arthritis Rheum] 2009 Aug; Vol. 39 (1), pp. 66-70. Date of Electronic Publication: 2008 Jun 09. - Publication Year :
- 2009
-
Abstract
- Objective: Our aim was to investigate a possible association between patterns of anti-dsDNA antibody isotypes (IgG, IgM, and IgA), rheumatoid factor (RF) isotypes (IgG, IgM, IgA), and IgG anti-C reactive protein (CRP) and systemic lupus erythematosus (SLE) disease activity (SLEDAI).<br />Methods: Our study group included 98 patients, 86 women and 12 men, with a mean SLEDAI score of 7.9 +/- 4.1. We divided the patients into 4 groups by the serum anti-dsDNA antibody isotype intensity level.<br />Results: We found that patients in group 1 (IgG > IgM, 42 patients) had a statistically significantly higher SLEDAI score than group 2 (IgG < IgM, 13 patients) (10.57 +/- 4.62 versus 5.6 +/- 4, P = 0.0012), group 3 (IgG = IgM, 8 patients) (10.57 +/- 4.62 versus 6.2 +/- 1.98, P = 0.04), and group 4 (none, 35 patients) (10.57 +/- 4.62 versus 6 +/- 1.5, P = 0.0001). SLE patients with IgG RF or IgM RF isotype present had a significantly higher SLEDAI score compared with those without IgG RF or IgM RF (10.57 +/- 4.8 versus 7.6 +/- 4.1, P = 0.03, 10.6 +/- 5 versus 7.6 +/- 3.9, P = 0.046). The presence of IgA RF isotype was not associated with a higher SLEDAI score. IgG anti-CRP did not correlate differentially with SLEDAI scores.<br />Conclusions: A combination of high-titer IgG anti-dsDNA with a positive RF of IgM isotype may serve as a marker for more active SLE.
- Subjects :
- Adolescent
Adult
Biomarkers blood
C-Reactive Protein metabolism
Female
Humans
Immunoglobulin G blood
Immunoglobulin M blood
Lupus Erythematosus, Systemic blood
Male
Middle Aged
Predictive Value of Tests
Prognosis
Retrospective Studies
Rheumatoid Factor blood
Young Adult
Antibodies, Antinuclear blood
DNA immunology
Lupus Erythematosus, Systemic diagnosis
Lupus Erythematosus, Systemic immunology
Severity of Illness Index
Subjects
Details
- Language :
- English
- ISSN :
- 1532-866X
- Volume :
- 39
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Seminars in arthritis and rheumatism
- Publication Type :
- Academic Journal
- Accession number :
- 18538829
- Full Text :
- https://doi.org/10.1016/j.semarthrit.2008.03.003