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Intravitreal triamcinolone for diabetic macular edema: comparison of 1, 2, and 4 mg.
- Source :
-
Retina (Philadelphia, Pa.) [Retina] 2008 Jun; Vol. 28 (6), pp. 825-30. - Publication Year :
- 2008
-
Abstract
- Purpose: To compare the efficacy and safety of different doses of intravitreal triamcinolone (IVTA) in treating eyes with refractory diffuse diabetic macular edema (DME) with cystic changes.<br />Methods: Forty-five eyes of 45 patients with diffuse DME were randomized to receive 1, 2, or 4 mg IVTA. Patients were observed for 6 months and changes in best-corrected visual acuity (VA) in Early Treatment Diabetic Retinopathy Study (ETDRS) scores, retinal thickness analyzer (RTA) central macular thickness (CMT), intraocular pressure, and cataract progression were compared among the three groups.<br />Results: Forty-two patients completed 6 months of follow-up and were included in the analysis. Following IVTA injection, the ETDRS score improved similarly, eight to nine letters, in all three groups at 4 weeks. The standardized CMT improved in all three groups at 4 weeks. This improvement was maintained through 12 and 24 weeks in the 1 and 2 mg groups, but not in the 4 mg group, which was significantly worse than the 1 and 2 mg groups at 12 and 24 weeks (P = 0.01, 0.03, 0.01, and 0.05).<br />Conclusions: Regarding eyes with refractory diffuse DME with cystic changes, 4 mg IVTA does not appear to be more effective than 1 or 2 mg IVTA.
- Subjects :
- Aged
Diabetic Retinopathy physiopathology
Follow-Up Studies
Glucocorticoids adverse effects
Humans
Injections
Intraocular Pressure
Macular Edema physiopathology
Middle Aged
Prospective Studies
Treatment Outcome
Triamcinolone Acetonide adverse effects
Visual Acuity
Vitreous Body
Diabetic Retinopathy drug therapy
Glucocorticoids administration & dosage
Macular Edema drug therapy
Triamcinolone Acetonide administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0275-004X
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Retina (Philadelphia, Pa.)
- Publication Type :
- Academic Journal
- Accession number :
- 18536598
- Full Text :
- https://doi.org/10.1097/IAE.0b013e318165767e