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Human umbilical cord blood-derived non-hematopoietic stem cells suppress lymphocyte proliferation and CD4, CD8 expression.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2008 Jul 15; Vol. 197 (2), pp. 99-109. Date of Electronic Publication: 2008 Jun 04. - Publication Year :
- 2008
-
Abstract
- One concern in the use of transplantation of non-hematopoietic stem cells from human umbilical cord blood (CB-nHSCs) is the possibility of rejection by the host's immune system. This study shows that both CB-nHSCs and their progenies after passaging, neuronal differentiation or IFN-gamma treatment have no significant effects on proliferation of xenogenic T lymphocytes. CB-nHSCs transplanted into the striatum of SD rat are shown to induce a lower level of CD4 and CD8 expression in the brain and in the peripheral blood and to survive better in the brain than SH-SY5Y cells. The results indicate that both undifferentiated and differentiated CB-nHSCs all have weak immunogenicity.
- Subjects :
- Analysis of Variance
Cell Differentiation drug effects
Cell Line, Transformed
Cell Proliferation
Corpus Striatum cytology
Corpus Striatum metabolism
Corpus Striatum transplantation
Cytokines metabolism
Enzyme-Linked Immunosorbent Assay methods
Flow Cytometry methods
Gene Expression drug effects
Humans
Interferon-gamma pharmacology
Intermediate Filament Proteins metabolism
Lymphocyte Activation drug effects
Lymphocyte Activation physiology
Nerve Tissue Proteins metabolism
Nestin
Neurons metabolism
Stem Cell Transplantation methods
Time Factors
Tubulin metabolism
CD4-Positive T-Lymphocytes metabolism
CD8-Positive T-Lymphocytes metabolism
Cell Differentiation physiology
Fetal Blood cytology
Gene Expression physiology
Stem Cells physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-5728
- Volume :
- 197
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 18534691
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2008.04.013