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Novel benzimidazole derivatives as selective CB2 agonists.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Jul 01; Vol. 18 (13), pp. 3695-700. Date of Electronic Publication: 2008 May 22. - Publication Year :
- 2008
-
Abstract
- The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (>1000-fold) over the CB1 receptor.
- Subjects :
- Benzimidazoles chemical synthesis
Binding, Competitive
Cannabinoid Receptor Modulators chemistry
Cannabinoids chemistry
Chemistry, Pharmaceutical methods
Drug Design
Humans
Models, Chemical
Receptor, Cannabinoid, CB1 chemistry
Receptors, Cannabinoid chemistry
Structure-Activity Relationship
Technology, Pharmaceutical methods
Benzimidazoles chemistry
Receptor, Cannabinoid, CB2 chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 18
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 18522867
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.05.073