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Potential role of CD8+CD28- T lymphocytes in immune activation during HIV-1 infection.
- Source :
-
AIDS (London, England) [AIDS] 2008 May 31; Vol. 22 (9), pp. 1083-6. - Publication Year :
- 2008
-
Abstract
- As CD8+CD28- T cells have been associated with dendritic and T cell suppression, we analyzed whether an increase in CD8+CD28- T cell numbers during HIV-1 infection could lead to impaired T cell responses. In contrast to the in-vitro generated CD8+CD28- suppressors, peripheral blood CD8+CD28- T cells of both HIV-infected and noninfected individuals promoted dendritic cell activation. The CD8+CD28- T cell accumulation during HIV-1 infection may thus contribute to accelerated inflammatory reactions and immune activation.
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 22
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 18520354
- Full Text :
- https://doi.org/10.1097/QAD.0b013e3282fce613