Back to Search
Start Over
Correlated light and electron microscopy illuminates the role of mitochondrial inner membrane remodeling during apoptosis.
- Source :
-
Biochimica et biophysica acta [Biochim Biophys Acta] 2008 Jul-Aug; Vol. 1777 (7-8), pp. 847-52. Date of Electronic Publication: 2008 May 24. - Publication Year :
- 2008
-
Abstract
- In addition to their role in providing ATP for cellular functions via oxidative phosphorylation, mitochondria also play a critical role in initiating and/or regulating apoptosis through the release of proteins such as cytochrome c from intermembrane and intracristal compartments. The mechanism by which these proteins are able to cross the outer mitochondrial membrane has been a subject of controversy. This paper will review some recent results that demonstrate that inner mitochondrial membrane remodeling does occur during apoptosis in HeLa cells but does not appear to be a requirement for release of cytochrome c from intracristal compartments. Inner membrane remodeling does appear to be related to fragmentation of the mitochondrial matrix, and the form of the remodeling suggests a topological mechanism for inner membrane fission and fusion.
Details
- Language :
- English
- ISSN :
- 0006-3002
- Volume :
- 1777
- Issue :
- 7-8
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta
- Publication Type :
- Academic Journal
- Accession number :
- 18510940
- Full Text :
- https://doi.org/10.1016/j.bbabio.2008.05.011