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Mechanisms of membrane fusion: disparate players and common principles.
- Source :
-
Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2008 Jul; Vol. 9 (7), pp. 543-56. Date of Electronic Publication: 2008 May 21. - Publication Year :
- 2008
-
Abstract
- Membrane fusion can occur between cells, between different intracellular compartments, between intracellular compartments and the plasma membrane and between lipid-bound structures such as viral particles and cellular membranes. In order for membranes to fuse they must first be brought together. The more highly curved a membrane is, the more fusogenic it becomes. We discuss how proteins, including SNAREs, synaptotagmins and viral fusion proteins, might mediate close membrane apposition and induction of membrane curvature to drive diverse fusion processes. We also highlight common principles that can be derived from the analysis of the role of these proteins.
- Subjects :
- Animals
Calcium metabolism
Cell Membrane ultrastructure
Lipid Bilayers chemistry
Lipid Bilayers metabolism
Membrane Proteins chemistry
Membrane Proteins metabolism
Models, Molecular
Protein Conformation
Protein Structure, Tertiary
SNARE Proteins chemistry
SNARE Proteins metabolism
Synaptic Vesicles metabolism
Synaptic Vesicles ultrastructure
Synaptotagmins chemistry
Synaptotagmins metabolism
Viral Fusion Proteins chemistry
Viral Fusion Proteins metabolism
Virus Internalization
Cell Membrane metabolism
Membrane Fusion physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-0080
- Volume :
- 9
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nature reviews. Molecular cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 18496517
- Full Text :
- https://doi.org/10.1038/nrm2417