Back to Search
Start Over
Germinal center B (GCB) and non-GCB cell-like diffuse large B cell lymphomas have similar outcomes following autologous haematopoietic stem cell transplantation.
Germinal center B (GCB) and non-GCB cell-like diffuse large B cell lymphomas have similar outcomes following autologous haematopoietic stem cell transplantation.
- Source :
-
British journal of haematology [Br J Haematol] 2008 Jul; Vol. 142 (3), pp. 404-12. Date of Electronic Publication: 2008 May 15. - Publication Year :
- 2008
-
Abstract
- Patients with germinal center B cell-like (GCB) and non-GCB diffuse large B cell lymphomas (DLBCL) receiving first line therapy have distinct prognosis. We explored the differences in outcome following salvage autologous hematopoietic stem cell (HSC) transplantation between patients with GCB and non-GCB DLBCL. Forty-four patients with relapsed and 15 patients with primary refractory chemosensitive disease undergoing BEAM (BCNU [carmustine], etoposide, cytarabine, melphalan) conditioning and autologous HSC were included. Immunohistochemical analysis was performed for CD10, BCL-6, MUM1 (allowing classification into GCB and non-GCB-like DLBCL) and BCL-2. Median follow-up of survivors was 25 months; median age at the time of transplantation was 60 years (range 17-77). Thirty-two patients (54%) were classified as having GCB and 27 (46%) as having non-GCB-like DLBCL. Patients with GCB and non-GCB DLBCL did not differ in the risk of progression after HSC transplant (P = 0.78) or overall survival (P = 0.48). In multivariate analysis, only time to progression after initial treatment impacted overall survival. We conclude that patients with relapsed or primary refractory chemosensitive GCB and non-GCB-like DLBCL derive similar benefit from autologous HSC transplant.
- Subjects :
- Adolescent
Adult
Aged
Biomarkers, Tumor analysis
Disease Progression
Female
Humans
Immunohistochemistry
Lymphoma, Large B-Cell, Diffuse pathology
Lymphoma, Large B-Cell, Diffuse therapy
Male
Middle Aged
Multivariate Analysis
Recurrence
Survival Rate
Transplantation, Autologous
Treatment Outcome
Young Adult
B-Lymphocytes pathology
Germinal Center pathology
Hematopoietic Stem Cell Transplantation
Lymphoma, Large B-Cell, Diffuse classification
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 142
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 18492096
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2008.07207.x