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Association between HCV and HBV infection in hepatocellular carcinoma and alcoholic liver disease.
- Source :
-
Journal of hepatology [J Hepatol] 1991 Jan; Vol. 12 (1), pp. 70-4. - Publication Year :
- 1991
-
Abstract
- We conducted a retrospective study in 229 patients to determine the prevalence of hepatitis C virus (HCV) according to the type of liver disease and also the serum hepatitis B virus (HBV) status. There were 55 cases of hepatocellular carcinoma (HCC), 78 cases of alcoholic cirrhosis (AC) and 96 cases of non-cirrhotic alcohol liver disease (NCA). Half the AC and NCA groups were constituted of patients with or without serum HBV markers. The prevalence of anti-HCV antibodies in HCC (58.2%) was significantly higher than in the other groups (AC, 35.9%; NCA, 17.7%). Combining the two AC and NCA groups gave a 25.8% anti-HCV prevalence in the alcoholics. Altogether anti-HCV antibodies were more frequently present in HBV-positive than in HBV-negative patients (42.2 vs. 26.1%, p less than 0.01), although the difference was not significant when the HCC group was separately analysed. The S/N ratio of anti-HCV-positive samples varied according to the type of the disease (tumorous vs. non-tumorous) and to the serum HBV status. Indeed, 65.6% of HCC had a S/N greater than 4 compared to only 32.2 and 23.5% in AC and NCA, respectively (p less than 0.01). On the other hand more than half of the AC and NCA had a S/N less than 2, indicating possible artefacts in certain cases. The 15 HBsAg and anti-HCV-positive patients had a significantly lower mean S/N than patients displaying only antibodies against HBV, even in the HCC group.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Aged
Carcinoma, Hepatocellular epidemiology
Carcinoma, Hepatocellular immunology
Female
France epidemiology
Hepatitis Antibodies blood
Hepatitis B epidemiology
Hepatitis B immunology
Hepatitis B Surface Antigens analysis
Hepatitis C epidemiology
Hepatitis C immunology
Humans
Liver microbiology
Liver pathology
Liver Cirrhosis, Alcoholic epidemiology
Liver Cirrhosis, Alcoholic immunology
Liver Neoplasms epidemiology
Liver Neoplasms immunology
Male
Middle Aged
Prevalence
Retrospective Studies
Carcinoma, Hepatocellular complications
Hepatitis B complications
Hepatitis C complications
Liver Cirrhosis, Alcoholic complications
Liver Neoplasms complications
Subjects
Details
- Language :
- English
- ISSN :
- 0168-8278
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 1848875
- Full Text :
- https://doi.org/10.1016/0168-8278(91)90912-u