Back to Search
Start Over
Common sequence variants on 20q11.22 confer melanoma susceptibility.
- Source :
-
Nature genetics [Nat Genet] 2008 Jul; Vol. 40 (7), pp. 838-40. Date of Electronic Publication: 2008 May 18. - Publication Year :
- 2008
-
Abstract
- We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 40
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 18488026
- Full Text :
- https://doi.org/10.1038/ng.163