Common sequence variants on 20q11.22 confer melanoma susceptibility.

Authors :: Brown KM
Macgregor S
Montgomery GW
Craig DW
Zhao ZZ
Iyadurai K
Henders AK
Homer N
Campbell MJ
Stark M
Thomas S
Schmid H
Holland EA
Gillanders EM
Duffy DL
Maskiell JA
Jetann J
Ferguson M
Stephan DA
Cust AE
Whiteman D
Green A
Olsson H
Puig S
Ghiorzo P
Hansson J
Demenais F
Goldstein AM
Gruis NA
Elder DE
Bishop JN
Kefford RF
Giles GG
Armstrong BK
Aitken JF
Hopper JL
Martin NG
Trent JM
Mann GJ
Hayward NK
Source :: Nature genetics [Nat Genet] 2008 Jul; Vol. 40 (7), pp. 838-40. Date of Electronic Publication: 2008 May 18.
Publication Year :: 2008
Abstract: We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.