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Emerging roles for neogenin and its ligands in CNS development.
- Source :
-
Journal of neurochemistry [J Neurochem] 2008 Aug; Vol. 106 (4), pp. 1483-92. Date of Electronic Publication: 2008 May 15. - Publication Year :
- 2008
-
Abstract
- It is now well established that the netrin guidance cues and their receptors comprise a major molecular guidance system driving axon pathfinding during nervous system development. One netrin receptor, neogenin, is now emerging as a key regulator of many developmental processes throughout the embryo. Unexpectedly, a new family of neogenin ligands, the repulsive guidance molecule (RGM) family, has recently been identified. The functional outcome of neogenin activation is dictated by both the nature of the ligand as well as the developmental context. Netrin-1-neogenin interactions mediate chemoattractive axon guidance, while RGMa-neogenin interactions repel axons. Neogenin is required for the establishment of the pseudostratified epithelium of the neural tube, probably by promoting cell adhesion. In addition, a role for RGMa and neogenin in neuronal differentiation has been demonstrated. While neogenin signaling cascades are poorly understood, the opposing responses of neogenin to RGMa and netrin-1 in the context of axon guidance indicates that neogenin signaling is complex and subject to tight spatiotemporal regulation. In summary, neogenin is a multifunctional receptor regulating diverse developmental processes. Thus, its contribution to neural development is proving to be considerably more extensive than originally predicted.
- Subjects :
- Amino Acid Sequence
Animals
Central Nervous System cytology
Humans
Ligands
Membrane Proteins chemistry
Membrane Proteins metabolism
Molecular Sequence Data
Central Nervous System embryology
Central Nervous System physiology
Gene Expression Regulation, Developmental physiology
Membrane Proteins physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-4159
- Volume :
- 106
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of neurochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18485097
- Full Text :
- https://doi.org/10.1111/j.1471-4159.2008.05485.x