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Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.
- Source :
-
Cancer letters [Cancer Lett] 2008 Oct 08; Vol. 269 (2), pp. 199-225. Date of Electronic Publication: 2008 May 13. - Publication Year :
- 2008
-
Abstract
- Because most cancers are caused by dysregulation of as many as 500 different genes, agents that target multiple gene products are needed for prevention and treatment of cancer. Curcumin, a yellow coloring agent in turmeric, has been shown to interact with a wide variety of proteins and modify their expression and activity. These include inflammatory cytokines and enzymes, transcription factors, and gene products linked with cell survival, proliferation, invasion, and angiogenesis. Curcumin has been found to inhibit the proliferation of various tumor cells in culture, prevents carcinogen-induced cancers in rodents, and inhibits the growth of human tumors in xenotransplant or orthotransplant animal models either alone or in combination with chemotherapeutic agents or radiation. Several phase I and phase II clinical trials indicate that curcumin is quite safe and may exhibit therapeutic efficacy. These aspects of curcumin are discussed further in detail in this review.
- Subjects :
- Animals
Breast Neoplasms prevention & control
Cell Proliferation drug effects
Clinical Trials as Topic
Curcumin chemistry
Curcumin pharmacokinetics
Curcumin therapeutic use
Gastrointestinal Neoplasms prevention & control
Humans
Interleukins antagonists & inhibitors
MAP Kinase Signaling System drug effects
NF-kappa B antagonists & inhibitors
Neoplasm Invasiveness
Neoplasm Metastasis prevention & control
PPAR gamma drug effects
STAT Transcription Factors antagonists & inhibitors
Transcription Factor AP-1 antagonists & inhibitors
Vascular Endothelial Growth Factor A antagonists & inhibitors
Angiogenesis Inhibitors pharmacology
Antineoplastic Agents pharmacology
Curcumin pharmacology
Neoplasms drug therapy
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7980
- Volume :
- 269
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 18479807
- Full Text :
- https://doi.org/10.1016/j.canlet.2008.03.009