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[Relationship of TCM syndrome type of gastric mucosal epithelial growth factor, vascular endothelial growth factor and proliferative cell nuclear antigen in patients with chronic atrophic gastritis].
- Source :
-
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine [Zhongguo Zhong Xi Yi Jie He Za Zhi] 2008 Mar; Vol. 28 (3), pp. 225-8. - Publication Year :
- 2008
-
Abstract
- Objective: To study the relationship of TCM syndrome type of gastric mucosal epithelial growth factor (EGF), vascular endothelial growth factor (VEGF) and proliferative cell nuclear antigen (PCNA) in patients with chronic atrophic gastritis (CAG) for exploring the essence of TCM type and providing a theoretical basis of clinical treatment.<br />Methods: TCM syndrome type of 200 patients with diagnosis of CAG confirmed by fibro-gastroscope and pathological examination were differentially classified, and the expressions of EGF, VEGF and PCNA in different types were determined using immunohistochemistry.<br />Results: Patients were differentiated as Pi-Wei deficiency type (Type I ) in 72; Gan-Wei disharmony type (Type II ) in 43; Pi-deficiency with qi stagnation type (Type III) in 32; Wei-yin deficiency type (Type IV) in 24; Pi-Wei damp-heat type (Type V) in 14; and Wei-collateral stasis obstruction type (Type VI) in 5. The difference of PCNA expression level between Type II with Type I , III and IV was significant (P < 0.05). No significant difference in expression levels of EGF and VEGF was found among the 6 types (P > 0.05).<br />Conclusion: Type I and II were the dominant TCM syndrome types in CAG patients; the high expression of PCNA might be a diagnostic evidence for Gan-Wei disharmony syndrome.
- Subjects :
- Adult
Aged
Aged, 80 and over
Diagnosis, Differential
Endothelial Growth Factors biosynthesis
Female
Gastric Mucosa pathology
Gastritis, Atrophic diagnosis
Humans
Immunohistochemistry
Male
Middle Aged
Syndrome
Gastric Mucosa metabolism
Gastritis, Atrophic metabolism
Medicine, Chinese Traditional
Proliferating Cell Nuclear Antigen biosynthesis
Vascular Endothelial Growth Factor A biosynthesis
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1003-5370
- Volume :
- 28
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
- Publication Type :
- Academic Journal
- Accession number :
- 18476422