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Limited small cell lung cancer: prognostic significance of a complete response to the induction phase of chemotherapy followed by thoracic irradiation.
Limited small cell lung cancer: prognostic significance of a complete response to the induction phase of chemotherapy followed by thoracic irradiation.
- Source :
-
Radiology [Radiology] 1991 Mar; Vol. 178 (3), pp. 875-8. - Publication Year :
- 1991
-
Abstract
- Limited-stage small cell lung cancer is frequently treated with induction combination chemotherapy (ICC), followed by consolidation with thoracic irradiation. It has been suggested that patients who do not have a complete response to ICC are unlikely to have control of occult distant metastasis and consequently have such a poor prognosis that thoracic irradiation is unlikely to be of benefit. To examine this hypothesis, 48 patients treated on prospective protocols who achieved a complete response to ICC or subsequently to thoracic irradiation were analyzed. Twenty-four patients had a complete response to ICC (CR-ICC), and 24 subsequently converted to complete-response status after thoracic irradiation (CR-TI). The two groups had similar prognostic factors and treatment. Comparing CR-ICC and CR-TI patients, survival was 40% versus 26% at 2 years and 35% versus 4% at 5 years, respectively (P less than .05). Freedom from distant metastasis was 41% at 5 years for the CR-ICC patients and 8% for the CR-TI patients (P less than .05). A modest number of CR-TI patients were long-term survivors, suggesting a value for thoracic irradiation as consolidation therapy.
- Subjects :
- Carcinoma, Small Cell drug therapy
Carcinoma, Small Cell radiotherapy
Cisplatin administration & dosage
Combined Modality Therapy
Cyclophosphamide administration & dosage
Doxorubicin administration & dosage
Etoposide administration & dosage
Female
Humans
Lung Neoplasms drug therapy
Lung Neoplasms radiotherapy
Male
Middle Aged
Prognosis
Vincristine administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Small Cell mortality
Lung Neoplasms mortality
Radiotherapy, High-Energy
Subjects
Details
- Language :
- English
- ISSN :
- 0033-8419
- Volume :
- 178
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 1847240
- Full Text :
- https://doi.org/10.1148/radiology.178.3.1847240