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Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro.
- Source :
-
Neuroscience letters [Neurosci Lett] 2008 Jun 13; Vol. 438 (1), pp. 17-21. Date of Electronic Publication: 2008 Apr 18. - Publication Year :
- 2008
-
Abstract
- As recent evidence has revealed a pro-survival role for the anti-obesity hormone leptin in the nervous system, we investigated the generality of this finding on cerebellar Purkinje and granule neurons in vitro. We found that whilst leptin promoted cerebellar Purkinje neuron survival, it had no affect on cerebellar granule cells. In addition, we discovered that leptin promoted both the outgrowth of neurites from cerebellar Purkinje neurons and increased the complexity of the neurite arbor. Thus, leptin has different effects on two neighbouring populations of neurons within the cerebellum implying specificity of its actions in the central nervous system.
- Subjects :
- Animals
Animals, Newborn
Cell Differentiation drug effects
Cell Survival drug effects
Cell Survival physiology
Cells, Cultured
Cerebellar Cortex cytology
Dendrites drug effects
Dendrites metabolism
Dose-Response Relationship, Drug
Leptin pharmacology
Mice
Mice, Inbred C57BL
Nerve Growth Factors pharmacology
Neurites drug effects
Neurites metabolism
Purkinje Cells drug effects
RNA, Messenger drug effects
RNA, Messenger metabolism
Receptors, Leptin agonists
Receptors, Leptin genetics
Receptors, Leptin metabolism
Cell Differentiation physiology
Cerebellar Cortex growth & development
Cerebellar Cortex metabolism
Leptin metabolism
Nerve Growth Factors metabolism
Purkinje Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 438
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 18472337
- Full Text :
- https://doi.org/10.1016/j.neulet.2008.04.045