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Role of interleukin-7 in degenerative and inflammatory joint diseases.
- Source :
-
Arthritis research & therapy [Arthritis Res Ther] 2008; Vol. 10 (2), pp. 107. Date of Electronic Publication: 2008 Apr 18. - Publication Year :
- 2008
-
Abstract
- IL-7 is known foremost for its immunostimulatory capacities, including potent T cell-dependent catabolic effects on bone. In joint diseases like rheumatoid arthritis and osteoarthritis, IL-7, via immune activation, can induce joint destruction. Now it has been demonstrated that increased IL-7 levels are produced by human articular chondrocytes of older individuals and osteoarthritis patients. IL-7 stimulates production of proteases by IL-7 receptor-expressing chondrocytes and enhances cartilage matrix degradation. This indicates that IL-7, indirectly via immune activation, but also by a direct action on cartilage, contributes to joint destruction in rheumatic diseases.
- Subjects :
- Animals
Humans
Arthritis metabolism
Interleukin-7 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6362
- Volume :
- 10
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Arthritis research & therapy
- Publication Type :
- Editorial & Opinion
- Accession number :
- 18466642
- Full Text :
- https://doi.org/10.1186/ar2395