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Chronic inflammation and CD16+ natural killer cell zeta-chain downregulation in hemodialysis patients.
- Source :
-
Blood purification [Blood Purif] 2008; Vol. 26 (4), pp. 317-21. Date of Electronic Publication: 2008 May 08. - Publication Year :
- 2008
-
Abstract
- Background: Natural killer (NK) cell activity is decreased in hemodialysis (HD) patients. Zeta-chain phosphorylation is an early event that follows the triggering of some NK cell-activating receptors. NK cell zeta-chain is downregulated in patients with cancer due to chronic inflammation. HD is also a chronic inflammatory state. NK cell zeta-chain expression in HD was evaluated.<br />Patients and Methods: Thirty-three HD patients and 30 healthy volunteers were enrolled into the study. The CD3-CD16+ subpopulation was examined, since it corresponds to 90% of all NK cells and has the highest cytotoxicity.NK cell count and zeta-chain mean fluorescence intensity were evaluated with flow cytometry. The inflammatory markers C-reactive protein, IL-6 and tumor necrosis factor-alpha were measured with ELISA.<br />Results: The inflammatory markers were increased in HD patients. NK cell count did not differ between HD patients and healthy volunteers. NK cell zeta-chain mean fluorescence intensity was decreased in the patient group.<br />Conclusions: Chronic inflammation could be responsible for the NK cell zeta- chain downregulation in HD patients, contributing to the decreased NK cell activity.<br /> ((c) 2008 S. Karger AG, Basel)
- Subjects :
- Aged
Biomarkers analysis
CD3 Complex
Case-Control Studies
Chronic Disease
Down-Regulation
Female
Flow Cytometry
Humans
Lymphocyte Count
Male
Middle Aged
Receptors, IgG
Renal Dialysis
Inflammation pathology
Kidney Failure, Chronic pathology
Killer Cells, Natural pathology
Receptors, Antigen, T-Cell analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9735
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Blood purification
- Publication Type :
- Academic Journal
- Accession number :
- 18463433
- Full Text :
- https://doi.org/10.1159/000130068