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CSF biomarkers in frontotemporal lobar degeneration with known pathology.
- Source :
-
Neurology [Neurology] 2008 May 06; Vol. 70 (19 Pt 2), pp. 1827-35. - Publication Year :
- 2008
-
Abstract
- Objective: To evaluate the diagnostic value of CSF biomarkers in patients with known pathology due to frontotemporal lobar degeneration (FTLD).<br />Background: It is important to distinguish FTLD from other neurodegenerative diseases like Alzheimer disease (AD), but this may be difficult clinically because of atypical presentations.<br />Methods: Patients with FTLD (n = 30) and AD (n = 19) were identified at autopsy or on the basis of genetic testing at University of Pennsylvania and Erasmus University Medical Center. CSF was obtained during a diagnostic lumbar puncture and was analyzed using assays for total tau and amyloid-beta 1-42 (A beta(42)). Patients also were assessed with a brief neuropsychological battery.<br />Results: CSF total tau level and the ratio of CSF total tau to A beta(42) (tau/A beta(42)) were significantly lower in FTLD than in AD. Receiver operating characteristic curve analyses confirmed that the CSF tau/A beta(42) ratio is sensitive and specific at discriminating between FTLD and AD, and is more successful at this than CSF total tau alone. Although some neuropsychological measures are significantly different in autopsy-proven FTLD and AD, combining these neuropsychological measures with CSF biomarkers did not improve the ability to distinguish FTLD from AD.<br />Conclusions: The ratio of CSF tau/A beta(42) is a sensitive and specific biomarker at discriminating frontotemporal lobar degeneration from Alzheimer disease in patients with known pathology.
- Subjects :
- Aged
Alzheimer Disease cerebrospinal fluid
Alzheimer Disease diagnosis
Alzheimer Disease physiopathology
Amyloid beta-Peptides analysis
Biomarkers analysis
Biomarkers cerebrospinal fluid
Brain physiopathology
Dementia physiopathology
Diagnosis, Differential
Disease Progression
Female
Humans
Male
Middle Aged
Neurofibrillary Tangles
Neuropsychological Tests
Peptide Fragments analysis
Plaque, Amyloid metabolism
Plaque, Amyloid pathology
Predictive Value of Tests
Prognosis
tau Proteins analysis
Amyloid beta-Peptides cerebrospinal fluid
Brain metabolism
Brain pathology
Dementia cerebrospinal fluid
Dementia pathology
Peptide Fragments cerebrospinal fluid
tau Proteins cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 1526-632X
- Volume :
- 70
- Issue :
- 19 Pt 2
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 18458217
- Full Text :
- https://doi.org/10.1212/01.wnl.0000311445.21321.fc