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Cancer related inflammation: the macrophage connection.
- Source :
-
Cancer letters [Cancer Lett] 2008 Aug 28; Vol. 267 (2), pp. 204-15. Date of Electronic Publication: 2008 Apr 29. - Publication Year :
- 2008
-
Abstract
- Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.
- Subjects :
- Animals
Cell Polarity
Disease Progression
Humans
Hypoxia-Inducible Factor 1, alpha Subunit metabolism
Inflammation complications
Macrophage Activation
Macrophages drug effects
NF-kappa B metabolism
Neoplasms drug therapy
Neoplasms etiology
STAT3 Transcription Factor metabolism
Inflammation immunology
Macrophages immunology
Neoplasms immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7980
- Volume :
- 267
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 18448242
- Full Text :
- https://doi.org/10.1016/j.canlet.2008.03.028