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Effects of oral administration of Stephania tetrandra S. Moore on neovascularization of retinal and choroidal capillaries of diabetes in rats.
- Source :
-
Phytotherapy research : PTR [Phytother Res] 2008 May; Vol. 22 (5), pp. 591-6. - Publication Year :
- 2008
-
Abstract
- In rats, an injection of streptozotocin (STZ) elevated blood levels of glucose 4 weeks later (STZ-induced diabetes) and an over-production of microvessels of retinal and choroidal capillaries of eyes developed. A previous study has shown that administration of Stephania tetrandra S. Moore (STSM) in culture prevented the over-production of microvessels of those capillaries of STZ-induced diabetes in vitro. Therefore, the study investigated whether or not orally administered STSM could inhibit over-production of microvessels of those capillaries of STZ injected rats in vivo. When STSM was given at the same time as the STZ injection and continued daily for 7 weeks, STSM prevented the elevation of blood glucose level and over-production of microvessels of those capillaries. When STSM was given after elevation of blood glucose level of glucose (4 weeks after STZ injection) and continued daily for 4 weeks, STSM lowered the elevated blood glucose level but had no effect on the over-production of microvessels of those capillaries. It was inferred that deposition of N(epsilon)(carboxymethyl) lysine in retinal and choroidal tissues, which is induced by STZ-induced diabetes may deteriorate the blood-retinal barrier and the blood-choroidal barrier. One might, therefore, speculate that advanced STZ-induced diabetes may deteriorate the blood-retinal barrier and blood-choroidal barrier. Therefore, STSM may not reach the retinal and choroidal tissues in the posterior ocular region in vivo.
- Subjects :
- Administration, Oral
Animals
Blood Glucose metabolism
Capillaries drug effects
Capillaries physiopathology
Choroidal Neovascularization physiopathology
Diabetes Mellitus, Experimental blood
Diabetes Mellitus, Experimental chemically induced
Male
Plant Extracts administration & dosage
Plant Extracts chemistry
Rats
Rats, Sprague-Dawley
Retinal Neovascularization physiopathology
Streptozocin
Choroidal Neovascularization prevention & control
Diabetes Mellitus, Experimental physiopathology
Plant Extracts pharmacology
Retinal Neovascularization prevention & control
Stephania tetrandra chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1573
- Volume :
- 22
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Phytotherapy research : PTR
- Publication Type :
- Academic Journal
- Accession number :
- 18444245
- Full Text :
- https://doi.org/10.1002/ptr.2202