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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Jun 01; Vol. 18 (11), pp. 3421-6. Date of Electronic Publication: 2008 Apr 04. - Publication Year :
- 2008
-
Abstract
- 5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as potent inhibitors of genotype 1 HCV NS5B polymerase focusing on the optimization of their drug metabolism and pharmacokinetics (DMPK) profiles. This investigation led to the discovery of potent inhibitors with improved DMPK properties.
- Subjects :
- Administration, Oral
Animals
Antiviral Agents chemistry
Combinatorial Chemistry Techniques
Drug Design
Haplorhini
Inhibitory Concentration 50
Models, Molecular
Molecular Structure
Pyridazines chemistry
Structure-Activity Relationship
Antiviral Agents chemical synthesis
Antiviral Agents pharmacokinetics
Hepacivirus enzymology
Pyridazines chemical synthesis
Pyridazines pharmacokinetics
Viral Nonstructural Proteins antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 18
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 18442904
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.04.005