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[Effects of Fructus Psoralea and Brucea javanica on the level of IL-2 and NK cell in rats infected with Pneumocystis carinii].
- Source :
-
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases [Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi] 2007 Oct; Vol. 25 (5), pp. 436-8. - Publication Year :
- 2007
-
Abstract
- SD rat model of PCP was established by subcutaneous injection with dexamethasone. The treatment groups received Fructus Psoralea (FP, 10.0 mg/kg), Brucea javanica (BJ, 1.2 mg/kg) and a mixture of the two Chinese herbs(FP 5mg/kg, BJ 0.6 mg/kg) respectively. By means of detecting the level of IL-2 in sera and NK cells in spleens, the effect of FP and BJ on the level of IL-2 and NK cells in rats with Pneumocystis carinii pneumonia (PCP) was observed, with SMZco treatment group (TMP 50 mg/kg, SMZ 250 mg/kg) and groups of infected and normal rats as controls. Compared with the infected group, the level of IL-2(526.1 +/- 5.5) pg/ml and NK cells (27.1% +/- 0.8%) significantly increased in the FP group (P < 0.01), followed by the FP/BJ combination group [(314.7 +/- 6.7) pg/ml, 22.9% +/- 0.9%) (P < 0.05)], and BJ group [(285.4 +/- 6.1) pg/ml, 20.7% +/- l.0%) (P < 0.05)]. Chinese herbs Fructus Psoralea and Brucea javanica show an immune regulatory action on the PCP rats.
- Subjects :
- Animals
Brucea chemistry
Cell Line, Tumor
Dexamethasone
Drug Combinations
Drugs, Chinese Herbal chemistry
Drugs, Chinese Herbal therapeutic use
Fabaceae chemistry
Female
Interleukin-2 blood
Killer Cells, Natural metabolism
Killer Cells, Natural microbiology
Mice
Phytotherapy
Pneumocystis Infections metabolism
Pneumocystis Infections microbiology
Pneumocystis carinii growth & development
Pneumonia, Pneumocystis chemically induced
Pneumonia, Pneumocystis prevention & control
Rats
Rats, Sprague-Dawley
Drugs, Chinese Herbal pharmacology
Interleukin-2 metabolism
Killer Cells, Natural drug effects
Pneumocystis Infections drug therapy
Pneumocystis carinii drug effects
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1000-7423
- Volume :
- 25
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
- Publication Type :
- Academic Journal
- Accession number :
- 18442007