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Involvement of nicotinic and muscarinic acetylcholine receptors on striatal HgCl2-induced dopamine release in freely moving rats.
- Source :
-
Toxicology letters [Toxicol Lett] 2008 May 30; Vol. 178 (3), pp. 181-4. Date of Electronic Publication: 2008 Mar 21. - Publication Year :
- 2008
-
Abstract
- The possible role of acetylcholine receptors on the HgCl(2)-induced dopamine (DA) release from rat striatum was investigated by using in vivo brain microdialysis technique after administration of selective nicotinic and muscarinic receptor antagonists, mecamylamine and atropine, respectively. Intrastriatal infusion of 1mM HgCl(2) increased striatal DA to 1717.2+/-375.4% respect to basal levels. Infusion of 1mM HgCl(2) in 1mM mecamylamine pretreated animals produced an increase on striatal DA levels 58% less than that induced in non-pretreated animals. In the case of atropine, this treatment reduced 62% the effect produced by HgCl(2) as compared to non-pretreated rats. These data show that acetylcholine receptors could participate on HgCl(2)-induced dopamine release since administration of nicotinic and muscarinic receptor antagonists reduces HgCl(2) effects on DA release.
- Subjects :
- Animals
Atropine pharmacology
Chromatography, High Pressure Liquid
Corpus Striatum metabolism
Drug Antagonism
Female
Mecamylamine pharmacology
Microdialysis
Muscarinic Antagonists pharmacology
Nicotinic Antagonists pharmacology
Rats
Rats, Sprague-Dawley
Anti-Infective Agents, Local toxicity
Corpus Striatum drug effects
Dopamine metabolism
Mercuric Chloride toxicity
Receptors, Muscarinic metabolism
Receptors, Nicotinic metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0378-4274
- Volume :
- 178
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Toxicology letters
- Publication Type :
- Academic Journal
- Accession number :
- 18439770
- Full Text :
- https://doi.org/10.1016/j.toxlet.2008.03.008