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Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
- Source :
-
Nature genetics [Nat Genet] 2008 Jun; Vol. 40 (6), pp. 710-2. Date of Electronic Publication: 2008 Apr 27. - Publication Year :
- 2008
-
Abstract
- We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.
- Subjects :
- Autophagy-Related Proteins
Carrier Proteins genetics
Case-Control Studies
Cohort Studies
Colitis, Ulcerative epidemiology
Crohn Disease epidemiology
GTP-Binding Proteins genetics
HLA-A Antigens genetics
Homeodomain Proteins genetics
Humans
Interleukin-12 Subunit p40 genetics
Intracellular Signaling Peptides and Proteins
Nod2 Signaling Adaptor Protein genetics
Protein Serine-Threonine Kinases genetics
Receptors, Interleukin genetics
Risk Factors
Biomarkers metabolism
Colitis, Ulcerative genetics
Crohn Disease genetics
Extracellular Matrix Proteins genetics
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 40
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 18438406
- Full Text :
- https://doi.org/10.1038/ng.145