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Retinal vascular caliber, blood pressure, and cardiovascular risk factors in an Asian population: the Singapore Malay Eye Study.
- Source :
-
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2008 May; Vol. 49 (5), pp. 1784-90. - Publication Year :
- 2008
-
Abstract
- Purpose: To describe the relationship of retinal vascular caliber with cardiovascular risk factors in an Asian population.<br />Methods: The Singapore Malay Eye Study is a population-based, cross-sectional survey that included 3280 (78.7% response) persons aged 40 to 80 years. Retinal vascular caliber was measured from digital retinal photographs using a validated standardized protocol. Data on major cardiovascular risk factors were collected from all participants.<br />Results: Of the 3019 participants with retinal vascular caliber data available, the mean retinal arteriolar caliber (CRAE) was 139.5 +/- 15.7 microm (SD), and mean venular caliber (CRVE) was 219.3 +/- 22.2 microm (SD). Smaller retinal arteriolar caliber was associated with higher current mean blood pressure and male sex (P < 0.001 for both). Larger retinal venular caliber was associated with younger age, current cigarette smoking, greater body mass index, higher glycosylated hemoglobin level, and lower HDL cholesterol (P = 0.012 for glycosylated hemoglobin level and P < 0.001 for other risk factors). The association of retinal arteriolar narrowing and blood pressure was stronger in younger people than in older people and in men than in women (P for interaction < 0.001 for both).<br />Conclusions: In this Asian population, smaller retinal arteriolar caliber was associated with hypertension and larger retinal venular caliber with cigarette smoking, dyslipidemia, hyperglycemia, and higher body mass index. The pattern of these associations is similar to that in white populations.
- Subjects :
- Adult
Age Factors
Aged
Aged, 80 and over
Body Mass Index
Cardiovascular Diseases ethnology
Cross-Sectional Studies
Dyslipidemias ethnology
Dyslipidemias etiology
Female
Humans
Hyperglycemia ethnology
Hyperglycemia etiology
Hypertension ethnology
Malaysia ethnology
Male
Middle Aged
Photography
Risk Factors
Sex Factors
Singapore epidemiology
Blood Pressure
Cardiovascular Diseases etiology
Hypertension etiology
Retinal Artery pathology
Retinal Vein pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0146-0404
- Volume :
- 49
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Investigative ophthalmology & visual science
- Publication Type :
- Academic Journal
- Accession number :
- 18436813
- Full Text :
- https://doi.org/10.1167/iovs.07-1450