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Fluoride uptake by plaque from water and from dentifrice.
- Source :
-
Journal of dental research [J Dent Res] 2008 May; Vol. 87 (5), pp. 461-5. - Publication Year :
- 2008
-
Abstract
- It has been suggested that fluoride retention in plaque is limited by available binding sites. We determined the effects of fluoridated or placebo dentifrices on plaque and salivary fluoride concentrations [F]s in communities with different water fluoride concentrations (0.04, 0.85, 3.5 ppm). After one week of dentifrice use, samples were collected 1.0 and 12 hrs after the last use of dentifrices. After the use of fluoridated dentifrice, plaque fluoride concentrations were higher at both times, except at 12 hrs in the 3.5-ppm community. Plaque concentrations at 1.0 hr after the use of fluoridated dentifrice increased almost constantly (6.5 mmol/kg), but then decreased approximately 50% at 12 hrs in each community. Unlike previous studies, the present findings suggest that the use of fluoridated dentifrice is likely to increase plaque fluoride concentrations significantly for up to 12 hrs in areas where the water contains fluoride close to 1.0 ppm. As previously reported, plaque fluoride concentrations were directly related to calcium concentrations.
- Subjects :
- Analysis of Variance
Calcium metabolism
Child
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Humans
Saliva metabolism
Time Factors
Treatment Outcome
Cariostatic Agents pharmacokinetics
Dental Plaque metabolism
Dentifrices pharmacokinetics
Fluoridation
Fluorides, Topical pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0022-0345
- Volume :
- 87
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of dental research
- Publication Type :
- Academic Journal
- Accession number :
- 18434577
- Full Text :
- https://doi.org/10.1177/154405910808700501