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Improvement of metal and tissue adhesion on surface-modified parylene C.
- Source :
-
Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2009 Apr; Vol. 89 (1), pp. 206-14. - Publication Year :
- 2009
-
Abstract
- A general method for chemical surface functionalization of parylene C [PC, (para-CH2-C6H3Cl-CH2-)n] films is reported. Friedel-Crafts acylation is used to activate the surface of the PC film, and the resulting carbonyl groups are then used to form a range of different organic functional groups to the surface of the parylene film, including alcohol, imine, thiol, phthalimide, amine, and maleimide. The presence of these functional groups on the parylene surface was confirmed by Fourier transform infrared spectroscopy. Static water drop contact angle measurements were also used to demonstrate the changes in hydrophilicity of the PC film surface, consistent with each of the surface modifications. Enhanced metal (gold) adhesion was achieved by anchoring a thiol group onto the acylated surface of PC film. Acylation of parylene with 2-chloropropionyl chloride gave a surface bound chloropropionyl group. Grafting of poly-N-isopropylacrylamide (pNIPAM) onto the chloropropionyl substituted PC film via atom transfer radical polymerization (ATRP) was carried out. The grafted pNIPAM on the parylene surface leads to temperature-dependent cellular tissue adhesion on the PC film.<br /> (Copyright 2008 Wiley Periodicals, Inc.)
- Subjects :
- Acrylamides chemistry
Acrylic Resins
Acylation
Animals
Biocompatible Materials chemistry
Biocompatible Materials metabolism
Female
Materials Testing
Molecular Structure
Polymers metabolism
Pregnancy
Rats
Rats, Sprague-Dawley
Surface Properties
Xylenes metabolism
Cell Adhesion physiology
Gold chemistry
Polymers chemistry
Xylenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4965
- Volume :
- 89
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of biomedical materials research. Part A
- Publication Type :
- Academic Journal
- Accession number :
- 18431781
- Full Text :
- https://doi.org/10.1002/jbm.a.31929