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Paraoxonase 1 (PON1) status in gastroesophageal malignancies and associated paraneoplastic syndromes - connection with inflammation.
- Source :
-
Clinical biochemistry [Clin Biochem] 2008 Jul; Vol. 41 (10-11), pp. 804-11. Date of Electronic Publication: 2008 Apr 04. - Publication Year :
- 2008
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Abstract
- Objective: To evaluate the status and diagnostic utility of antioxidant paraoxonase 1 (PON1) in gastroesophageal cancers.<br />Design and Methods: PON1's arylesterase/paraoxonase activities and phenotype were determined in 82 cancers and 57 controls, and related to clinicopathological features, anemia and cachexia coexistence, cholesterol levels, liver function panel, and inflammatory and angiogenic indices.<br />Results: PON1's activities were decreased in cancer. Arylesterase activity correlated with cancer T and N stages, being an N1-independent predictor. Both activities correlated with transferrin, albumin, CRP and inflammation-based Glasgow Prognostic Score, and arylesterase activity also with interleukin-6 and midkine. Phenotype A (Q192 homozygotes) was associated with lower transferrin and higher TNF-alpha concentrations. PON1's arylesterase activity reflected anemia severity, being correlated with hemoglobin, hematocrit, and iron. PON1 arylesterase activity negatively correlated with alkaline phosphatase and gamma-glutamyl transferase, but not with bilirubin, aminotransferases, HDL or LDL cholesterol. PON1 moderately indicated cancer presence and regional metastasis.<br />Conclusions: PON1 activity decreases in gastroesophageal cancers and corresponds to inflammation severity and cancer-related anemia. PON1 decrease indicates lymph node metastasis, but its moderate predictive power does not recommend PON1 determination alone for clinical application.
- Subjects :
- Adenocarcinoma complications
Adenocarcinoma enzymology
Adenocarcinoma physiopathology
Adult
Aged
Aged, 80 and over
Anemia blood
Anemia enzymology
Anemia etiology
Carcinoma, Squamous Cell complications
Carcinoma, Squamous Cell enzymology
Carcinoma, Squamous Cell physiopathology
Esophageal Neoplasms pathology
Esophageal Neoplasms physiopathology
Female
Humans
Inflammation enzymology
Inflammation etiology
Male
Middle Aged
Neoplasm Staging
Paraneoplastic Syndromes pathology
Paraneoplastic Syndromes physiopathology
Stomach Neoplasms pathology
Stomach Neoplasms physiopathology
Aryldialkylphosphatase blood
Esophageal Neoplasms complications
Esophageal Neoplasms enzymology
Paraneoplastic Syndromes enzymology
Paraneoplastic Syndromes etiology
Stomach Neoplasms complications
Stomach Neoplasms enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2933
- Volume :
- 41
- Issue :
- 10-11
- Database :
- MEDLINE
- Journal :
- Clinical biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18423402
- Full Text :
- https://doi.org/10.1016/j.clinbiochem.2008.03.012