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A digenic combination of polymorphisms within ESR1 and ESR2 genes are associated with age at menarche in the Spanish population.
- Source :
-
Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2008 Apr; Vol. 15 (3), pp. 305-11. - Publication Year :
- 2008
-
Abstract
- In the present study, the authors look at an association of genetic variants within estrogen synthesis and signaling pathways and age at menarche (AAM) in Spanish women. They analyzed 9 polymorphisms in 6 different genes in 714 well-characterized postmenopausal women from Spain. They performed a quantitative trait locus study of these markers individually or in digenic combinations in relation to AAM. None of the studied markers, with the exception of the follicle-stimulating hormone receptor (P = .013), were significantly associated with AAM in the Spanish population, and no marker demonstrated an association of statistical significance after multiple testing corrections (P > .0055). In contrast, linear regression analysis suggests epistatic interactions including ESR1 and ESR2 loci in relation to AAM in the series (P = .003). The results suggest that epistatic interactions of ESR1 and ESR2 alleles could be associated with advancing AAM among Spanish women.
- Subjects :
- Adolescent
Age Factors
Aged
Aging metabolism
Child
Estrogen Receptor alpha metabolism
Estrogen Receptor beta metabolism
Estrogens biosynthesis
Female
Gene Frequency
Genotype
Humans
Logistic Models
Menarche metabolism
Middle Aged
Phenotype
Postmenopause genetics
Signal Transduction genetics
Spain
Aging genetics
Epistasis, Genetic
Estrogen Receptor alpha genetics
Estrogen Receptor beta genetics
Menarche genetics
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1933-7205
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Reproductive sciences (Thousand Oaks, Calif.)
- Publication Type :
- Academic Journal
- Accession number :
- 18421025
- Full Text :
- https://doi.org/10.1177/1933719107314064