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Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero Diels-Alder reaction and evaluation of antimicrobial activity.

Authors :
Manjula MK
Rai KM
Gaonkar SL
Raveesha KA
Satish S
Source :
European journal of medicinal chemistry [Eur J Med Chem] 2009 Jan; Vol. 44 (1), pp. 280-8. Date of Electronic Publication: 2008 Mar 07.
Publication Year :
2009

Abstract

A new series of 5,6-dihydro-4H-1,2-oxazines were synthesized via hetero Diels-Alder reaction of alpha-nitrosoolefins with alkenes. alpha-Nitrosoolefins were generated from ketoximes by the action of chloramine-T. The newly synthesized compounds were characterized with IR, NMR, elemental analysis and screened for their antimicrobial activity; they exhibited excellent antimicrobial activity. The minimal inhibitory concentration of the compounds was in the range of 10-35 microg ml(-1) for bacteria and 10-40 microg ml(-1) for fungi.

Details

Language :
English
ISSN :
1768-3254
Volume :
44
Issue :
1
Database :
MEDLINE
Journal :
European journal of medicinal chemistry
Publication Type :
Academic Journal
Accession number :
18420309
Full Text :
https://doi.org/10.1016/j.ejmech.2008.02.027