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[Correlation between the effect of chemotherapy on complement conformation and on CA-125 antigen in the blood plasma of patients with ovarian carcinoma].
- Source :
-
Voprosy onkologii [Vopr Onkol] 2007; Vol. 53 (6), pp. 696-8. - Publication Year :
- 2007
-
Abstract
- Correlation was investigated between blood-plasma levels of C3(H2)O (conformation pattern of C3 component of the complement) and tumor-associated marker CA-125 in patients with ovarian cancer before and after chemotherapy. Since a drop in CA-125 level after chemotherapy was associated with similar changes in C3(H2)O fraction, it seems reasonable to suggest that change in conformation of C3 is a response of the immune system to cancer.
- Subjects :
- Animals
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Female
Humans
Mice
Protein Conformation drug effects
Antineoplastic Combined Chemotherapy Protocols pharmacology
CA-125 Antigen blood
CA-125 Antigen drug effects
Complement C3 drug effects
Complement C3 metabolism
Ovarian Neoplasms drug therapy
Ovarian Neoplasms metabolism
Subjects
Details
- Language :
- Russian
- ISSN :
- 0507-3758
- Volume :
- 53
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Voprosy onkologii
- Publication Type :
- Academic Journal
- Accession number :
- 18416140