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[Mechanisms underlying changes in functional properties of red cells in acute action of carbon monoxide].
- Source :
-
Patologicheskaia fiziologiia i eksperimental'naia terapiia [Patol Fiziol Eksp Ter] 2008 Jan-Mar (1), pp. 18-20. - Publication Year :
- 2008
-
Abstract
- It has been experimentally established that a single impact of carbon mono-oxide in concentration 4000 mg/m3 during 75 minutes (CL50) in rats is accompanied with disturbance of functional activities of blood red cells in the form of a decrease of deformability and an increase of aggregative capacity of erythrocytes which are most evident to the end of the first day after carbon mono-oxide administration. These changes are combined with structural modification and changes in metabolism of erythrocytic membrane. The signs of structural modification of erythrocytic membrane in rats exposed to acute effect of carbon mono-oxide in a mean lethal concentration stay long remaining during elimination of carboxyhemoglobinemia (up to 14-21 days).
- Subjects :
- Animals
Carboxyhemoglobin analysis
Dose-Response Relationship, Drug
Erythrocyte Membrane drug effects
Erythrocyte Membrane metabolism
Erythrocytes metabolism
Erythrocytes physiology
Lipid Metabolism drug effects
Lipid Peroxidation drug effects
Male
Rats
Rats, Wistar
Carbon Monoxide toxicity
Carbon Monoxide Poisoning blood
Erythrocytes drug effects
Subjects
Details
- Language :
- Russian
- ISSN :
- 0031-2991
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Patologicheskaia fiziologiia i eksperimental'naia terapiia
- Publication Type :
- Academic Journal
- Accession number :
- 18415972