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[The investigation of HEV epidemiology, inferior clinical infection and viral-toxemia in blood donors in Quzhou area].
- Source :
-
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology [Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi] 2008 Feb; Vol. 22 (1), pp. 45-7. - Publication Year :
- 2008
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Abstract
- Objective: To investigate the infection of HEV in Quzhou area of Zhejiang Province.<br />Methods: All sera from blood donors in the central blood bank of Quzhou from April 2006 to April 2007 were used. Anti-HEV IgG and anti-HEV IgM were measured by EIA. RT-PCR was also performed to the samples with positive anti-HEV IgM. Genotype and sequence homology were analyzed after sequencing.<br />Results: The positive ratio of anti-HEV IgG was 40.60%, in which the male infection ratio was higher than the female significantly (43.09% VS 36.09%; chi2=22.6; P < 0.01). The infection ratio was increased with age. The positive ratio of anti-HEV IgM was 0.43%. The positive ratio of anti-HEV IgG and the titers of antibody were higher in the inferior clinical infectors with positive anti-HEV IgM than the negative ones (P < 0.05). Two samples were positive in HEV PCR among 21 samples with positive anti-HEV IgM. The toxemia ratio was 0.4% of all the donors. And the genotype of the two samples with toxemia were both HEV-IV.<br />Conclusion: The HEV infection was correlation with age and sex significantly and the infection occurred in the adults mainly in Quzhou area. HEV toxemia was not infrequency in the blood donors.
- Subjects :
- Adolescent
Adult
Age Factors
Antibodies, Viral analysis
Antibodies, Viral immunology
China epidemiology
Female
Genotype
Hepatitis E immunology
Hepatitis E virology
Hepatitis E virus genetics
Hepatitis E virus immunology
Humans
Immunoglobulin G analysis
Immunoglobulin G immunology
Immunoglobulin M analysis
Immunoglobulin M immunology
Male
Middle Aged
Sequence Analysis, DNA
Sequence Homology
Sex Factors
Toxemia virology
Blood Donors
Hepatitis E complications
Hepatitis E epidemiology
Toxemia complications
Toxemia epidemiology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1003-9279
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology
- Publication Type :
- Academic Journal
- Accession number :
- 18414699