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Quantification of porcine circovirus type 2 (PCV-2) within- and between-pen transmission in pigs.

Authors :
Andraud M
Grasland B
Durand B
Cariolet R
Jestin A
Madec F
Rose N
Source :
Veterinary research [Vet Res] 2008 Sep-Oct; Vol. 39 (5), pp. 43. Date of Electronic Publication: 2008 Apr 17.
Publication Year :
2008

Abstract

PCV-2 within- and between-pen transmission was quantified by estimating the daily transmission rate beta and the basic reproduction ratio (R(0)) using a stochastic SEIR (Susceptible, Exposed, Infectious, Removed) model fitted on experimental data. Within-pen transmission was quantified by using four groups of eight SPF (specific pathogen-free) pigs (four infected and four susceptible pigs having direct contact). Between-pen transmission was studied in two groups of 16 SPF pigs (eight infected and eight susceptible pigs having indirect contact (10 cm distance)). Pigs were monitored twice a week (blood samples) and were tested for PCV-2 antibodies (ELISA test) and viral genome load in sera (real-time PCR). Transmission parameters beta(within) and beta(between) were estimated using a maximum likelihood method and the duration of infectiousness, to compute R(0), was estimated with a parametric survival model. Different assumptions were made to determine the end of infectiousness (seroconversion, seroconversion and decline in viral genome load, permanent infectiousness). R(0[within]) (8.9 (5.1-15.4)) was greater when the end of infectiousness was assumed to be related to both seroconversion and a decline of PCV-2 genome load in sera (average duration of infectiousness = 32 days) compared with only seroconversion as the indicator of recovery (R(0[within]) = 5.5 (3.3-9.0)). Whatever the assumption, between-pen R(0) (0.58 (0.23-1.47)) was always significantly lower than within-pen R(0). Only beta(within) was sensitive to the assumption on end of infectiousness and decreased with increasing duration of infectiousness. These results showed that PCV-2 transmission is influenced by contact structure that appears worth being taken into account in an epidemic model.

Details

Language :
English
ISSN :
0928-4249
Volume :
39
Issue :
5
Database :
MEDLINE
Journal :
Veterinary research
Publication Type :
Academic Journal
Accession number :
18413131
Full Text :
https://doi.org/10.1051/vetres:2008020