Back to Search
Start Over
CD127 immunophenotyping suggests altered CD4+ T cell regulation in primary progressive multiple sclerosis.
- Source :
-
Journal of autoimmunity [J Autoimmun] 2008 Aug; Vol. 31 (1), pp. 52-8. Date of Electronic Publication: 2008 Apr 11. - Publication Year :
- 2008
-
Abstract
- Aberrant regulatory T cell populations, characterised by a wide array of CD markers, have been identified in many autoimmune diseases. CD127 has recently been identified as a specific marker for the CD4(+)CD25(Hi) (Tregs) subset. CD127 is the first non-HLA gene to have its association with multiple sclerosis widely replicated. We demonstrate that the regulatory or suppressor T cells CD4(+)CD25(Hi) (Tregs), CD8(+)CD28(-), and CD3(+)CD56(+) (NKT) all produce low levels of CD127, and so could be at a disadvantage in survival and/or proliferation where IL7 is limiting. The remissions seen in relapsing remitting multiple sclerosis (RRMS) could be driven by regulatory T cells, and the absence of remissions seen in primary progressive MS (PPMS) may point to a particularly reduced function of this cell subset. We found that the proportions of CD4(+)FoxP3(+)CD25(Hi) regulatory T cells were not aberrant in PPMS. There was, however, a trend towards reduced FoxP3 expression per cell in this fraction (p<0.083), which has been highly correlated with suppressor function. Notably, we found that the target of regulatory T cells, the CD4(+)CD25(-) cells, was in excess (p<0.009); and in PPMS a protective CD127 haplotype is correlated with higher CD127 expression (p<0.01). These data support further investigations into the regulatory T cell immunophenotype in MS.
- Subjects :
- Adult
Antigens, Surface immunology
Cell Separation
Female
Flow Cytometry
Forkhead Transcription Factors biosynthesis
Forkhead Transcription Factors immunology
Humans
Immunophenotyping
Interleukin-7 Receptor alpha Subunit immunology
Male
Middle Aged
Multiple Sclerosis, Chronic Progressive pathology
Multiple Sclerosis, Relapsing-Remitting pathology
T-Lymphocyte Subsets immunology
T-Lymphocyte Subsets metabolism
T-Lymphocyte Subsets pathology
T-Lymphocytes, Regulatory metabolism
T-Lymphocytes, Regulatory pathology
Antigens, Surface biosynthesis
Interleukin-7 Receptor alpha Subunit biosynthesis
Multiple Sclerosis, Chronic Progressive immunology
Multiple Sclerosis, Relapsing-Remitting immunology
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0896-8411
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of autoimmunity
- Publication Type :
- Academic Journal
- Accession number :
- 18406576
- Full Text :
- https://doi.org/10.1016/j.jaut.2008.02.003