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Pediatric liver transplant: results of a single center.
- Source :
-
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation [Exp Clin Transplant] 2008 Mar; Vol. 6 (1), pp. 7-13. - Publication Year :
- 2008
-
Abstract
- Objectives: Liver transplant in the pediatric population has become an accepted treatment modality for children with end-stage liver disease. In this study, we analyze our experiences with pediatric liver transplant at our center.<br />Materials and Methods: Since September 2001, 8 deceased-donor and 96 living-donor liver transplants have been done in 101 children (mean age, 6.7 +/- 5.5 years; range, 2 months to 17 years). The children's charts were reviewed retrospectively.<br />Results: Indications for liver transplant were cholestatic liver disease (n=17), biliary atresia (n=24), Wilson's disease (n=16), fulminant liver failure (n=18), hepatic tumor (n=13), and other (n=13). The median pediatric end-stage liver disease score was 23.1 +/- 11.1 (range, -8 to 48). The median follow-up was 24.2 +/- 19.4 months (range, 1-77 months). Three children underwent retransplant. The main complications were infections (25.9%) and surgical complications (39.5%) (including biliary complications and vascular problems). The incidence of acute cellular rejection was 42.3%. Sixteen children died during follow-up, and, at the time of this writing, the remaining 85 children (85%) were alive with good graft functioning, showing patient survival rates of 90%, 85%, and 83% at 6, 12, and 36 months, respectively.<br />Conclusions: In conclusion, the overall outcomes of pediatric liver transplantation at our center are quite promising.
- Subjects :
- Adolescent
Biliary Atresia surgery
Cadaver
Child
Child, Preschool
Cholestasis, Intrahepatic surgery
Follow-Up Studies
Graft Rejection
Hepatolenticular Degeneration surgery
Humans
Infant
Liver Failure, Acute surgery
Liver Neoplasms surgery
Living Donors
Postoperative Complications
Reoperation
Retrospective Studies
Survival Rate
Treatment Outcome
Liver Transplantation mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1304-0855
- Volume :
- 6
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 18405239