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Preparation and characterization of solid lipid nanoparticles loaded with alpha-Asarone.
- Source :
-
PDA journal of pharmaceutical science and technology [PDA J Pharm Sci Technol] 2008 Jan-Feb; Vol. 62 (1), pp. 56-65. - Publication Year :
- 2008
-
Abstract
- This work investigated the potential of solid lipid nanoparticles (SLNs) to improve oral bioavailablity and tissue uptake of a poorly soluble drug, alpha-Asarone. Ultrasonic homogenization method was employed to prepare alpha-Asarone-loaded SLNs (alpha-Asarone-SLNs). Particle size and distribution, pH, viscosity, drug incorporation and zeta potential of the SLNs were investigated. Pharmacokinetic study of oral administration to male rats at 10 mg/Kg suggested that the relative bioavailability of alpha-Asarone was significantly improved in alpha-Asarone-SLN group compared to alpha-Asarone solution group. Comparison of alpha-Asarone-SLN to alpha-Asarone control solution for alpha-Asarone concentrations in rat tissue showed an increased uptake of alpha-Asarone in brain and lung for the ARE-SLN group. These results indicate that alpha-Asarone-SLNs significantly enhance the absorption and tissue distribution of alpha-Asarone. SLNs offer a new approach to improve the oral bioavailability of poorly soluble drugs.
- Subjects :
- Allylbenzene Derivatives
Animals
Anisoles blood
Anisoles chemistry
Biological Availability
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Fibrinolytic Agents blood
Fibrinolytic Agents chemistry
Intestinal Absorption
Male
Microscopy, Electron, Transmission
Particle Size
Rats
Rats, Wistar
Tissue Distribution
Anisoles pharmacokinetics
Fibrinolytic Agents pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1079-7440
- Volume :
- 62
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- PDA journal of pharmaceutical science and technology
- Publication Type :
- Academic Journal
- Accession number :
- 18402368