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Rosetting is associated with increased Plasmodium falciparum in vivo multiplication rate in the Saimiri sciureus monkey.

Authors :
Le Scanf C
Vigan-Womas I
Contamin H
Guillotte M
Bischoff E
Mercereau-Puijalon O
Source :
Microbes and infection [Microbes Infect] 2008 Apr; Vol. 10 (4), pp. 447-51. Date of Electronic Publication: 2007 Dec 28.
Publication Year :
2008

Abstract

Severe Plasmodium falciparum malaria in African children is associated with high peripheral parasite densities and high rate of rosette-forming parasites. To explore the relationship between rosette formation and parasite density in vivo, we compared the multiplication rate of a rosette-forming variant (varO) of the Palo Alto line with a sibling non-rosetting variant (varR) in splenectomized Saimiri monkeys. The multiplication rate of varO parasites was 1.5-fold higher than that of the varR variant. This indicates that rosetting is indeed associated with high parasite multiplication efficiency in vivo and, as such, may contribute to the high parasite densities observed in severe malaria.

Details

Language :
English
ISSN :
1286-4579
Volume :
10
Issue :
4
Database :
MEDLINE
Journal :
Microbes and infection
Publication Type :
Academic Journal
Accession number :
18400545
Full Text :
https://doi.org/10.1016/j.micinf.2007.12.012