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Uric acid and renal function in multiple sclerosis.
- Source :
-
La Clinica terapeutica [Clin Ter] 2008 Jan-Feb; Vol. 159 (1), pp. 35-40. - Publication Year :
- 2008
-
Abstract
- Objective: The purpose of this study was to examine the circadian distribution of creatinine and uric acid clearances in subjects with Multiple Sclerosis.<br />Materials and Methods: Eleven subjects with MS, 6 women (48+/-7y) and 5 men (58+/-5y) volunteered for this circadian study. Thirteen healthy females (39+/-11y) served as controls. Data of seven healthy male controls (64+/-8 y) were extracted from a similar circadian study conducted previously. Each MS patient, and each male control had blood samples drawn around the clock, at 3h intervals (8/24h), and each collected urines over 3h periods (8/24h). Each female control contributed only one blood sample and one complete 24h urine collection. Blood and urine samples were analyzed for a number of relevant analytes: ELAM, IL-6, NO, insulin, ACTH, aldosterone, cortisol, electrolytes, lymphocytes, monocytes including creatinine and uric acid clearances. Those were standardized to an average body surface area of 1.73 m2.<br />Results: The relevant analytes demonstrated increased synthesis of insulin, IL-6, ELAM, monocytes, and reduced concentrations of serum NO. The creatinine clearances were significantly lower in MS females than in female controls, 63+/-22 vs.108+/-18 ml/min. They were also lower than those of MS males and male controls, 107.8+/-17, 97.5+/-8.2 ml/min. Uric acid clearances in MS females were also lower 6.9+/-2.4 vs. 10.5+/-4.4 ml/min. The uric acid clearance in MS males was higher than in male controls, 7.0+/-4.5 vs. 4.0+/-1.0 ml/min.<br />Conclusions: The alterations in selected relevant analytes and the reduced creatinine and uric acid clearances in females but not in males, suggest a renal dysfunction in MS females. These observations may contribute to understanding better the mechanism of renal dysfunction in female patients and perhaps this may be an additional factor contributing to greater frequency of MS in females than in male subjects.
- Subjects :
- Adult
Aged
Biomarkers blood
Biomarkers urine
Case-Control Studies
Creatinine blood
Creatinine urine
Female
Humans
Kidney Failure, Chronic blood
Kidney Failure, Chronic urine
Kidney Function Tests
Male
Middle Aged
Sex Distribution
Virginia
Antioxidants analysis
Circadian Rhythm
Multiple Sclerosis blood
Multiple Sclerosis urine
Uric Acid blood
Uric Acid urine
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9074
- Volume :
- 159
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- La Clinica terapeutica
- Publication Type :
- Academic Journal
- Accession number :
- 18399261