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Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity, and their clinical relevance.
- Source :
-
In vivo (Athens, Greece) [In Vivo] 2008 Jan-Feb; Vol. 22 (1), pp. 115-21. - Publication Year :
- 2008
-
Abstract
- This study examined possible interactions between immunological abnormalities and symptoms in CFS. Sixteen CFS patients filled in a battery of questionnaires, evaluating daily functioning, and underwent venous blood sampling, in order to analyse immunological abnormalities. Ribonuclease (RNase) L cleavage was associated with RNase L activity (rs=0.570; p=0.021), protein kinase R (PKR) (rs=0.716; p=0.002) and elastase activity (rs=0.500; p=0.049). RNase L activity was related to elastase (rs=0.547; p=0.028) and PKR activity (rs=0.625; p=0.010). RNase L activity (rs=0.535; p=0.033), elastase activity (rs=0.585; p=0.017) and RNase L cleavage (rs=0.521; p=0.038) correlated with daily functioning. This study suggests that in CFS patients an increase in elastase activity and subsequent RNase L cleavage is accompanied by increased activity of both the PKR and RNase L enzymes. RNase L and elastase activity are related to daily functioning, thus evidence supporting the clinical importance of these immune dysfunctions in CFS patients was provided.
- Subjects :
- Adolescent
Adult
Aged
Disability Evaluation
Fatigue Syndrome, Chronic blood
Fatigue Syndrome, Chronic physiopathology
Female
Health Status
Humans
Immune System physiopathology
Lymphocytes enzymology
Male
Middle Aged
Monocytes enzymology
Quality of Life
Surveys and Questionnaires
Endoribonucleases metabolism
Fatigue Syndrome, Chronic enzymology
Immune System metabolism
Pancreatic Elastase metabolism
eIF-2 Kinase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0258-851X
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- In vivo (Athens, Greece)
- Publication Type :
- Academic Journal
- Accession number :
- 18396793