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Effect of a novel ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate, on normal human dermal fibroblasts against reactive oxygen species.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2008 Apr; Vol. 72 (4), pp. 1015-22. Date of Electronic Publication: 2008 Apr 07. - Publication Year :
- 2008
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Abstract
- The novel amphiphilic vitamin C derivative disodium isostearyl 2-O-L-ascorbyl phosphate (VCP-IS-2Na), which has a C(18) alkyl chain attached to the stable ascorbate derivative sodium L-ascorbic acid 2-phosphate (VCP-Na), was evaluated for reduction of cell damage induced by oxidative stress, ultraviolet A (UVA), ultraviolet B (UVB), and H(2)O(2); stimulation of collagen synthesis against UVA irradiation; and inhibition of matrix metalloproteinase-1 (MMP-1) activity induced by UVA in human normal dermal fibroblasts. VCP-IS-2Na pretreatment resulted in significant protection against cell damage induced by UVB, UVA, and H(2)O(2). The amount of type I collagen following UVA irradiation was increased by treatment with VCP-IS-2Na in a concentration-dependent manner. These effects of VCP-IS-2Na were superior to those of L-ascorbic acid (vitamin C, VC) and VCP-Na. On the other hand, VCP-IS-2Na suppressed 65% of the excess MMP-1 irradiated UVA, and VC and VCP-Na slightly suppressed it.
- Subjects :
- Animals
Ascorbic Acid analysis
Ascorbic Acid pharmacology
Cattle
Cell Survival drug effects
Collagen metabolism
Fibroblasts metabolism
Fibroblasts radiation effects
Humans
Matrix Metalloproteinase 1 metabolism
Oxidative Stress drug effects
Ultraviolet Rays
Antioxidants pharmacology
Ascorbic Acid analogs & derivatives
Dermis cytology
Fibroblasts drug effects
Reactive Oxygen Species metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1347-6947
- Volume :
- 72
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18391439
- Full Text :
- https://doi.org/10.1271/bbb.70766