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SAPHO syndrome with rapidly progressing destructive spondylitis: two cases treated surgically.
- Source :
-
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society [Eur Spine J] 2008 Sep; Vol. 17 Suppl 2, pp. S331-7. Date of Electronic Publication: 2008 Apr 04. - Publication Year :
- 2008
-
Abstract
- The authors present two cases of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome with rapidly progressing destructive spondylitis treated surgically. The spinal lesions in SAPHO syndrome generally have a good prognosis and rarely cause the structural destruction or neurological deterioration. Case 1: a 63-year-old female had palmoplantar pustulosis for 2 years. At first, she only felt a pain in the nape with no inducing factor. Two months later, she had incomplete quadriplegia (ASIA scale C). Magnetic resonance imaging showed destruction of C4-C7, kyphotic deformity, and severe compression of the spinal cord. Decompression and reconstruction surgery using anterior and posterior approach improved her paralysis. Case 2: a 69-year-old female complained of persistent back pain. Magnetic resonance imaging revealed spondylitis of T7-T9. Although there were no typical skin lesions, we diagnosed SAPHO syndrome by hyperostosis of the sternocostoclavicular joint and sacral joint. Destruction with kyphotic deformity of the spine progressed gradually for 3 months. Curettage and reconstruction surgery using thoracic endoscope relieved her pain and prevented the destruction of the spine. The histopathology of the specimen obtained surgically showed non-specific inflammation in both cases. Spondylitis in SAPHO syndrome may cause severe destruction and kyphotic deformity followed by paralysis.
- Subjects :
- Aged
Cervical Vertebrae pathology
Cervical Vertebrae physiopathology
Cervical Vertebrae surgery
Decompression, Surgical instrumentation
Decompression, Surgical methods
Disease Progression
Endoscopy
Female
Humans
Hyperostosis complications
Hyperostosis pathology
Hyperostosis physiopathology
Kyphosis pathology
Kyphosis surgery
Magnetic Resonance Imaging
Middle Aged
Paralysis etiology
Paralysis pathology
Paralysis surgery
Plastic Surgery Procedures instrumentation
Plastic Surgery Procedures methods
Spinal Cord Compression pathology
Spinal Cord Compression surgery
Spondylitis pathology
Sternoclavicular Joint pathology
Sternoclavicular Joint physiopathology
Thoracic Vertebrae pathology
Thoracic Vertebrae physiopathology
Thoracic Vertebrae surgery
Treatment Outcome
Acquired Hyperostosis Syndrome complications
Kyphosis etiology
Spinal Cord Compression etiology
Spondylitis etiology
Spondylitis surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0932
- Volume :
- 17 Suppl 2
- Database :
- MEDLINE
- Journal :
- European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 18389286
- Full Text :
- https://doi.org/10.1007/s00586-008-0663-4