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Cholesterol in women at high cardiovascular risk is less successfully treated than in corresponding men. The Skaraborg Hypertension and Diabetes Project.
- Source :
-
European journal of clinical pharmacology [Eur J Clin Pharmacol] 2008 Aug; Vol. 64 (8), pp. 815-20. Date of Electronic Publication: 2008 Apr 04. - Publication Year :
- 2008
-
Abstract
- Objective: To assess the use of lipid-lowering therapy in patients with known coronary heart disease (CHD), cerebrovascular disease or diabetes in a community-based population in Sweden considering expert recommendations.<br />Methods: A random sample of individuals aged > or =40 years who were surveyed in 1993-1994 were revisited 10 years later during 2003-2004 (n = 724). A clinical investigation focused on cardiovascular risk including serum total cholesterol. Information on medical history and current medication was collected in structured interviews.<br />Results: Eighty-two patients (11.3%) reported a history of CHD, including 51 men and 31 women. Fifty-three patients fulfilled criteria for treatment and most of them (85%) were on lipid-lowering therapy. A higher fraction of women were treated; however only 13% of them reached target cholesterol levels compared to 37% of the men (P < 0.001). Sixty-five subjects (9.0%) had diabetes and/or a previous stroke (29 men, 36 women) but no previous CHD. Patients with CHD were more likely to be treated compared to patients with diabetes and/or stroke but no CHD (85.0 vs. 28.5%, OR 6.0, 95% CI 2.2-16.9, P = 0.01). In a total of 79 participants (10.9%) who were on lipid-lowering therapy, women reached a total serum cholesterol level below 5.0 mmol/L less often than men (26.3 vs. 63.4%, P < 0.001).<br />Conclusions: A considerable proportion of patients in primary care were untreated despite current guidelines on lipid-lowering therapy. Treatment outcome in women was less efficient compared with men. Strategies to improve pharmacological treatment in these patients should be developed.
- Subjects :
- Aged
Aged, 80 and over
Cholesterol blood
Coronary Disease complications
Coronary Disease drug therapy
Data Collection
Diabetes Complications prevention & control
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prejudice
Risk Factors
Sex Factors
Stroke complications
Stroke drug therapy
Sweden epidemiology
Cardiovascular Diseases prevention & control
Hyperlipidemias drug therapy
Hypolipidemic Agents therapeutic use
Practice Guidelines as Topic
Subjects
Details
- Language :
- English
- ISSN :
- 0031-6970
- Volume :
- 64
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 18389228
- Full Text :
- https://doi.org/10.1007/s00228-008-0482-x