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Trisomy of chromosome 6 in Merkel cell carcinoma within lymph nodes.
- Source :
-
Virchows Archiv : an international journal of pathology [Virchows Arch] 2008 May; Vol. 452 (5), pp. 559-63. - Publication Year :
- 2008
-
Abstract
- Merkel cell carcinoma (MCC) of the skin is a neuroendocrine tumor with characteristic histological and immunohistochemical features. Among various cytogenetic changes, trisomy of chromosome 6 has been reported in 47% of cases using in situ hybridization. Primary tumors, morphologically and immunohistochemically identical to MCCs of the skin, have been described in other organs, including lymph nodes. Here, a cytogenetic study of four cases of MCC of lymph nodes is presented. Four cases of primary MCCs of lymph nodes and ten cases of cutaneous MCCs were studied for chromosome 6 using fluorescent in situ hybridization (FISH). All cases showed typical features of MCC both at hematoxylin and eosin (H&E) and immunohistochemistry. FISH showed trisomy 6 in two out of the four cases ofMCCs of lymph node as well as in 6 out 10 cases of MCCs of skin. Lymph nodal and cutaneous MCCs share same histological and immunohistochemical features, as well as same cytogenetic alteration for chromosome 6. It seems that there are more similarities than differences between cutaneous and lymph nodal MCCs. Whether lymph nodal MCCs are primary tumors or metastases from regressed skin lesions is still questionable, although several findings indicate a primary origin.
- Subjects :
- Aged
Aged, 80 and over
Carcinoma, Merkel Cell pathology
Cytogenetics
Female
Humans
In Situ Hybridization, Fluorescence
Lymphatic Metastasis pathology
Male
Middle Aged
Skin Neoplasms pathology
Carcinoma, Merkel Cell genetics
Chromosomes, Human, Pair 6
Lymphatic Metastasis genetics
Skin Neoplasms genetics
Trisomy
Subjects
Details
- Language :
- English
- ISSN :
- 0945-6317
- Volume :
- 452
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Virchows Archiv : an international journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 18386054
- Full Text :
- https://doi.org/10.1007/s00428-008-0599-4