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Signaling and regulatory mechanisms of integrin alphavbeta6 on the apoptosis of colon cancer cells.
- Source :
-
Cancer letters [Cancer Lett] 2008 Aug 08; Vol. 266 (2), pp. 209-15. Date of Electronic Publication: 2008 Apr 01. - Publication Year :
- 2008
-
Abstract
- Considerable researches have been done about integrin alphanubeta6 and carcinomas, but little information has been shown about the relationship between integrin alphanubeta6 and apoptosis. In this study, we investigated the apoptosis and its related signal pathways to integrin alphavbeta6 in colon cancer cells. After we blocked the function of integrin alphavbeta6 in HT29 cells used the monoclonal antibody, the apoptotic cells increased markedly. Meanwhile, cytochrome C released from mitochondria into cytosol, Bcl-2 decreased while Bax increased significantly, and Fas and Fas-ligand had no change. The activities of caspase-3 and caspase-9 increased, while caspase-8 remained no change. Moreover, the expression of phosphorylated extracellular signal-related kinase (P-ERK) decreased. We confirmed that integrin alphavbeta6 acted as an important role in inhibiting apoptosis in colon cancer cells, and the signaling involved the mitochondrial pathway.
- Subjects :
- Antibodies pharmacology
Antigens, Neoplasm immunology
Caspases metabolism
Colonic Neoplasms pathology
Cytochromes c metabolism
Extracellular Signal-Regulated MAP Kinases metabolism
HT29 Cells
Humans
Integrins antagonists & inhibitors
Integrins immunology
Mitochondria metabolism
Proto-Oncogene Proteins c-bcl-2 metabolism
bcl-2-Associated X Protein metabolism
Antigens, Neoplasm physiology
Apoptosis
Colonic Neoplasms metabolism
Integrins physiology
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3835
- Volume :
- 266
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 18381232
- Full Text :
- https://doi.org/10.1016/j.canlet.2008.02.054