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Radiocontrast increases plasma and urinary endothelin.
- Source :
-
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 1991 Nov; Vol. 2 (5), pp. 1041-5. - Publication Year :
- 1991
-
Abstract
- Recent studies indicate that endothelin (ET), a potent endogenous systemic and renal vasoconstrictor peptide, may mediate decreases in GFR in models of acute renal dysfunction. Moreover, in an animal model of radiocontrast-induced nephropathy (RCIN), it was recently demonstrated that early renal hemodynamic responses to radiocontrast are attenuated by intra-arterial atrial natriuretic factor (ANF), which prevents subsequent RCIN. The studies presented here were therefore designed to determine whether i.v. infusion of radiocontrast produces increases in endogenous plasma and urinary ET and whether these responses are modulated by intra-arterial ANF in an animal model of RCIN. In these studies, dogs with pacing-induced heart failure received i.v. radiocontrast in the presence and absence of an intra-aortic infusion of ANF. Significant increases in both plasma and urinary ET were observed during and after radiocontrast. Although coadministration of ANF did not prevent increases in plasma and urinary ET, ANF preserved renal function acutely in this model of RCIN by increasing GFR above baseline levels.
- Subjects :
- Acute Kidney Injury etiology
Acute Kidney Injury physiopathology
Acute Kidney Injury prevention & control
Animals
Atrial Natriuretic Factor administration & dosage
Contrast Media administration & dosage
Dogs
Drug Combinations
Endothelins urine
Female
Glomerular Filtration Rate drug effects
Heart Failure complications
Iothalamate Meglumine administration & dosage
Iothalamic Acid administration & dosage
Male
Contrast Media toxicity
Endothelins blood
Iothalamate Meglumine toxicity
Iothalamic Acid toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1046-6673
- Volume :
- 2
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of the American Society of Nephrology : JASN
- Publication Type :
- Academic Journal
- Accession number :
- 1836965
- Full Text :
- https://doi.org/10.1681/ASN.V251041