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Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2008 Apr 14; Vol. 205 (4), pp. 883-95. Date of Electronic Publication: 2008 Mar 24. - Publication Year :
- 2008
-
Abstract
- FcgammaRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or function predisposes to autoimmunity. To determine if increased expression of FcgammaRIIb can modulate these processes, we created transgenic mice overexpressing FcgammaRIIb on B cells or macrophages. Overexpression of FcgammaRIIb on B cells reduced the immunoglobulin G component of T-dependent immune responses, led to early resolution of collagen-induced arthritis (CIA), and reduced spontaneous systemic lupus erythematosus (SLE). In contrast, overexpression on macrophages had no effect on immune responses, CIA, or SLE but increased mortality after Streptococcus pneumoniae infection. These results help define the role of FcgammaRIIb in immune responses, demonstrate the contrasting roles played by FcgammaRIIb on B cells and macrophages in the control of infection and autoimmunity, and emphasize the therapeutic potential for modulation of FcgammaRIIb expression on B cells in inflammatory and autoimmune disease.
- Subjects :
- Animals
Arthritis, Experimental
B-Lymphocytes cytology
B-Lymphocytes enzymology
B7-2 Antigen immunology
Bacterial Infections
Cell Proliferation
Extracellular Signal-Regulated MAP Kinases metabolism
Humans
Immunoglobulin G immunology
Lupus Erythematosus, Systemic immunology
Macrophages immunology
Mice
Mice, Transgenic
Organ Specificity
Phosphorylation
T-Lymphocytes immunology
Transgenes
Antigens, CD immunology
Autoimmunity immunology
Infections immunology
Receptors, IgG immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 205
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 18362174
- Full Text :
- https://doi.org/10.1084/jem.20072565