Back to Search
Start Over
SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2008 May 23; Vol. 370 (1), pp. 195-9. Date of Electronic Publication: 2008 Mar 24. - Publication Year :
- 2008
-
Abstract
- We identified human decapping enzyme 2 (hDCP2) as a binding protein with Ro52, being colocalized in processing bodies (p-bodies). We also showed that the N-terminus and C-terminus of Ro52 bound to hDCP2. Moreover, Ro52 enhanced decapping activity of hDCP2 in a dose-dependent manner. Our data support the novel notion of the association between Ro52 with hDCP2 protein in cytoplasmic p-bodies, playing a role in mRNA metabolism in response to cellular stimulation.
- Subjects :
- Autoantigens analysis
Catalysis
Cytoplasm enzymology
Endoribonucleases analysis
Endoribonucleases genetics
Humans
Protein Interaction Mapping
Protein Structure, Tertiary
Ribonucleoproteins analysis
Ribonucleoproteins genetics
Autoantigens metabolism
Endoribonucleases metabolism
RNA Caps metabolism
RNA Stability
Ribonucleoproteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 370
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 18361920
- Full Text :
- https://doi.org/10.1016/j.bbrc.2008.03.075