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Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory.
- Source :
-
Behavioural brain research [Behav Brain Res] 2008 Jun 26; Vol. 190 (1), pp. 147-51. Date of Electronic Publication: 2008 Feb 16. - Publication Year :
- 2008
-
Abstract
- The APP23 model is a transgenic mouse model for Alzheimer's disease. Cognitive performance in the APP23-model was assessed by Morris Water Maze (MWM) and passive avoidance learning, but the latter failed to show any difference between the genotypes. In search of a non-spatial alternative for assessment of hippocampus-dependent memory, we evaluated an odour paired-associate test, which is based on learning an association between two sets of odours. The protocol includes a shaping phase, in which the animals learn to dig up a reward, a preliminary training phase and a training phase, where the actual association is learned. Subsequently, mice are tested for transitive inference and subjected to a symmetry test. Impairment was seen in the APP23 mice, in comparison with wild type mice, in training; however, both groups failed the transitivity and symmetry test. Possible explanations for this discrepancy with earlier published results are the advanced age of the mice or the C57Bl/6J background, in which the model was established.
- Subjects :
- Age Factors
Analysis of Variance
Animals
Disease Models, Animal
Humans
Maze Learning
Mice
Mice, Inbred C57BL
Mice, Transgenic
Psychomotor Performance physiology
Random Allocation
Alzheimer Disease genetics
Alzheimer Disease pathology
Alzheimer Disease physiopathology
Amyloid beta-Protein Precursor genetics
Association Learning physiology
Hippocampus physiopathology
Memory physiology
Odorants
Subjects
Details
- Language :
- English
- ISSN :
- 0166-4328
- Volume :
- 190
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 18359101
- Full Text :
- https://doi.org/10.1016/j.bbr.2008.02.014