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Genetic variants of tumor necrosis factor superfamily, member 4 (TNFSF4), and risk of incident atherothrombosis and venous thromboembolism.
- Source :
-
Clinical chemistry [Clin Chem] 2008 May; Vol. 54 (5), pp. 833-40. Date of Electronic Publication: 2008 Mar 20. - Publication Year :
- 2008
-
Abstract
- Background: Recent data have implicated tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4) gene variation in myocardial infarction in women; however, no prospective data are available on either incident arterial or venous disorders.<br />Methods: We evaluated 2 previously characterized TNFSF4 gene variants (-921C>T and dbSNP rs3850641) with a) incident arterial events using a prospective case-cohort design with 344 incident CVD cases and 2254 control participants, all white, drawn from the Women's Health Study cohort with 10 years of follow-up, and b) venous thromboembolism (VTE) risk using a nested, matched case-control design of 108 white male pairs (drawn from the Physicians' Health Study cohort) and a case-cohort design of white female participants consisting of 125 cases and 2269 controls (drawn from the Women's Health Study cohort), analyzed separately.<br />Results: Genotype distributions were in Hardy-Weinberg equilibrium. Results from a marker-by-marker regression analysis, adjusting for traditional risk factors, showed a significant association of -921C>T with an increased risk of VTE in women (additive: odds ratio 1.86; 95% CI 1.17-2.92, P = 0.008) in women. Furthermore, using a haplotype-based regression analysis, haplotype C-G was associated with a reduced risk of VTE relative to the referent haplotype, C-A (odds ratio 0.50; 95% CI 0.27-0.92; P = 0.02). In contrast, we found little evidence for an association of the variants/haplotypes with risk of VTE in men or CVD risk in women (as previously reported).<br />Conclusions: Our present findings, if corroborated in other prospective investigations, suggest that the TNFSF4 variants tested may be useful indicators for assessing the risk of venous thromboembolism.
- Subjects :
- Adult
Aged
Aged, 80 and over
Atherosclerosis genetics
Brain Ischemia complications
Case-Control Studies
Coronary Disease epidemiology
Coronary Disease genetics
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Myocardial Infarction epidemiology
Myocardial Infarction genetics
Polymorphism, Genetic
Prospective Studies
Risk
Stroke epidemiology
Stroke etiology
Stroke genetics
Thrombosis genetics
Venous Thromboembolism epidemiology
Venous Thromboembolism genetics
Atherosclerosis epidemiology
OX40 Ligand genetics
Thrombosis epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9147
- Volume :
- 54
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18356244
- Full Text :
- https://doi.org/10.1373/clinchem.2007.096479